CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Hepatic YB–1 activation occurs by different mechanisms and mediates Mrp2 suppression and MMP–2 induction during endotoxemia
DOI 10.1055/s-2008-1037560
Bibliografische Angaben
Nachweis in CareLit
Autor:innenIV Martin, PR Mertens, B Frye, S Strauch, T Rauen, C Trautwein, A Geier
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aim: Expression of hepatobiliary transporters is decreased during inflammatory cholestasis. Reduction of Mrp2 is mediated by IL–1ß-dependent signals but the underlying mechanism is still unclear. YB–1 is a predominantly cytoplasmic protein which translocates to the nucleus in response to various insults and has previously been characterized as a transcriptional repressor of rat Mrp2 and inductor of MMP–2. Consequent…
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Zitierempfehlung
IV Martin, PR Mertens, B Frye, S Strauch, T Rauen, C Trautwein, A Geier (2008) Hepatic YB–1 activation occurs by different mechanisms and mediates Mrp2 suppression and MMP–2 induction during endotoxemia. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2008-1037560
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