CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Cytochrome P4502E1 is responsible for miscoding etheno-Dna adducts induced by ethanol in the liver
DOI 10.1055/s-2008-1037563
Bibliografische Angaben
Nachweis in CareLit
Autor:innenY Wang, J Nair, S Mueller, F Stickel, H Bartsch, HK Seitz
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Chronic alcohol consumption leads to hepatic cirrhosis and hepatocellular cancer (HCC) possibly via oxidative stress. Ethanol induces cytochrome P4502E1 (CYP2E1) resulting in the generation of reactive oxygen species (ROS) which cause lipidperoxidation. Lipid peroxidation products such as 4-hydroxynonenal (4HNE) can finally react with DNA forming exocyclic etheno-DNA adducts with high mutagenic and carcinogenic prop…
Zitieren
Zitierempfehlung
Y Wang, J Nair, S Mueller, F Stickel, H Bartsch, HK Seitz (2008) Cytochrome P4502E1 is responsible for miscoding etheno-Dna adducts induced by ethanol in the liver. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-2008-1037563
Mit CareLit weiterarbeiten