CareLit · DOI-Nachweis · Klinische Neurophysiologie
Loss of Extinction in CA1-NMDA Receptor deficient Mice. A novel model for PTSD?
DOI 10.1055/s-2008-1072883
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Autor:innenS Hirsch, J Blundell, S Birnbaum, C Powell, R Greene
ZeitschriftKlinische Neurophysiologie
Ausgabe04/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Hippocampal NMDA receptors are involved in contextual fear learning. Here we report that a gene deletion of the NR1 subunit of the NMDA receptor, localized to CA1 neurons of the dorsal hippocampus via AAV-Cre injection in fNR1 mice, results in a selective loss of fear memory extinction, but not its acquisition. Furthermore, CA1-NMDA receptor deficient mice show enhanced anxiety and hyperactivity after fear condition…
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Zitierempfehlung
S Hirsch, J Blundell, S Birnbaum, C Powell, R Greene (2008) Loss of Extinction in CA1-NMDA Receptor deficient Mice. A novel model for PTSD?. Klinische Neurophysiologie (04). https://doi.org/10.1055/s-2008-1072883
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