CareLit · DOI-Nachweis · Pneumologie
Nanohale – PEI(-PEG)/siRNA nanoscale complexes, inducing RNA interference (RNAi), for systemic and local siRNA delivery to the lung
DOI 10.1055/s-2008-1074267
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Malek, A Aigner, O Merkel, F Czubayko, T Kissel
ZeitschriftPneumologie
Ausgabe04/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
RNA interference (RNAi) is a powerful strategy to inhibit the expression of any (pathologically relevant) gene of interest. It is mediated through small interfering RNAs (siRNAs) which trigger specific mRNA degradation. Their instability and poor delivery into target tissues, however, so far severely limits their therapeutic use and requires the development of nanoscale delivery systems. Polyethylenimines (PEIs) are…
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Zitierempfehlung
A Malek, A Aigner, O Merkel, F Czubayko, T Kissel (2008) Nanohale – PEI(-PEG)/siRNA nanoscale complexes, inducing RNA interference (RNAi), for systemic and local siRNA delivery to the lung. Pneumologie (04). https://doi.org/10.1055/s-2008-1074267
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