CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
The Glyoxalase I (GLO-1) system as modulator of pain in early diabetic neuropathy
DOI 10.1055/s-2008-1076183
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS Stoyanov, T Fleming, I Konrade, GM Haag, PM Humpert, N Rabbani, P Thornalley, M Brownlee, PP Nawroth, A Bierhaus
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe04/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Diabetic neuropathy (DN) is a major complication of diabetes, however, the molecular mechanisms underlying increased pain in early stages of the disease are yet poorly understood. We have recently demonstrated that hyperglycemia-dependent, RAGE-mediated suppression of glyoxalase-1 (GLO-1), the major cellular defence in the detoxification of methylglyoxal (MG) contributes to increased pain in early phas…
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Zitierempfehlung
S Stoyanov, T Fleming, I Konrade, GM Haag, PM Humpert, N Rabbani, P Thornalley, M Brownlee, PP Nawroth, A Bierhaus (2008) The Glyoxalase I (GLO-1) system as modulator of pain in early diabetic neuropathy. Diabetologie und Stoffwechsel (04). https://doi.org/10.1055/s-2008-1076183
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