CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
The endothelial thrombomodulin system protects against diabetic nephropathy through two independent mechanisms: role of the lectin-like domain
DOI 10.1055/s-2008-1076243
Bibliografische Angaben
Nachweis in CareLit
Autor:innenIA Vinnikov, M Kashif, M Thati, SUE Herzog, PP Nawroth, B Isermann
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe04/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Objective: The thrombomodulin (TM) protein C (PC) system is an endothelial dependent, cytoprotective system which has been initially identified based on its anticoagulant function. Following binding and inactivation of thrombin the complex of TM and thrombin activates PC via its EGF-domains 4–6. Activated PC (APC) has anticoagulant as well as cytoprotective properties. In addition TM mediates a direct cytoprotective…
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Zitierempfehlung
IA Vinnikov, M Kashif, M Thati, SUE Herzog, PP Nawroth, B Isermann (2008) The endothelial thrombomodulin system protects against diabetic nephropathy through two independent mechanisms: role of the lectin-like domain. Diabetologie und Stoffwechsel (04). https://doi.org/10.1055/s-2008-1076243
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