CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
The genetic variation in the IDE (insulin degrading enzyme) gene is associated with impaired insulin metabolism and increased risk of type 2 diabetes
DOI 10.1055/s-2008-1076445
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Nachweis in CareLit
Autor:innenN Rudovich, O Pivovarova, E Fisher, M Osterhof, M Moehlig, J Spranger, P Slominsky, H Boeing, M Schulze, AFH Pfeiffer
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe04/2008
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: Evidence for linkage of type 2 diabetes to a region on chromosome 10q23-q25 has been provided in several populations. Among genes in this region is IDE encoding insulin degrading enzyme which serve as a major enzyme responsible for insulin proteolysis. IDE knockout mice show a diabetic phenotype with hyperinsulinemia. Thus, the aim of the present study was to examine the genetic associations between IDE SNPs,…
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Zitierempfehlung
N Rudovich, O Pivovarova, E Fisher, M Osterhof, M Moehlig, J Spranger, P Slominsky, H Boeing, M Schulze, AFH Pfeiffer (2008) The genetic variation in the IDE (insulin degrading enzyme) gene is associated with impaired insulin metabolism and increased risk of type 2 diabetes. Diabetologie und Stoffwechsel (04). https://doi.org/10.1055/s-2008-1076445
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