Zusammenfassung

     Zusammenfassung Ziel der Studie Ziel des Vorhabens ist die Untersuchung regionaler Unterschiede in der Konzentration von Thyreoidea-stimulierendem Hormon (TSH), freiem Thyroxin (fT4) und des Jodstatus in komparablen deutschen und europäischen Kohortenstudien. Methodik Die geschlechts- und altersstratifizierten TSH-, fT4- und Urin-Jodkonzentrationen der anamnestisch schilddrüsengesunden Teilnehmer (Altersgruppe 45–75 Jahre) der HNR (Heinz Nixdorf Recall) Studie im Ruhrgebiet Deutschlands, der süddeutschen KORA (Kooperative Gesundheitsforschung in der Region Augsburg) und nordostdeutschen SHIP (Study of Health in Pomerania) Studie sowie der norwegischen HUNT (Nord-Trøndelag Health) Studie (Altersgruppe 40–79 Jahre), der englischen EPIC (European Prospective Investigation of Cancer)-Norfolk Studie und der niederländischen Rotterdam Studie wurden miteinander verglichen. Der TSH-Referenzbereich für die HNR Studienpopulation wurde berechnet und der KORA und SHIP Studie gegenübergestellt. Ergebnisse Regionale Unterschiede zeigten in der Altersgruppe der 45- bis 75- Jährigen einen stärkeren Einfluss auf die TSH- und fT4-Konzentrationen als das Geschlecht und das Alter der Probanden. Die geschätzte Differenz der Mediane, gemessen an der HNR Studie, war mit −0,47 (95% KI: −0,53; −0,41) für die Männer und −0,41 (−0,53; −0,41) für die Frauen in der SHIP Studie am geringsten. Die Rotterdam Studie wies sowohl für Männer als auch Frauen die höchste Differenz der Mediane (Männer: 0,56 mit 0,44; 0,68 und Frauen: 0,62 mit 0,46; 0,78) auf. Die geringsten medianen TSH-Konzentrationen wurden, über alle betrachteten Alterskategorien, in den deutschen Kohorten beobachtet. Schlussfolgerung Der Vergleich der Schilddrüsenfunktionsparameter und Jod bei älteren Probanden zwischen sechs vergleichbaren Kohortenstudien aus Deutschland und Europa zeigte einen bedeutenden Einfluss der Region, welcher die Geschlechts- und Altersabhängigkeit der Parameter überstieg. Abstract Aim of the study The aim of the project was to investigate regional differences in thyroid stimulating hormone (TSH), and free thyroxine (fT4) concentrations and iodine status in comparable German and European cohort studies. Methods Sex- and age-stratified TSH, fT4, and urine iodine concentrations of thyroid-healthy participants (age group 45–75 years) of the HNR (Heinz Nixdorf Recall) Study in the Ruhr region of Germany, the southern German KORA (Cooperative Health Research in the Augsburg Region) and northeastern German SHIP (Study of Health in Pomerania) studies, as well as the Norwegian HUNT (Nord-Trøndelag Health) study (age group 40–79 years), the English EPIC (European Prospective Investigation of Cancer)-Norfolk study, and the Dutch Rotterdam study were compared. The TSH reference range for the HNR study population was calculated and compared to the KORA and SHIP studies. Results Regional differences showed a stronger influence on TSH and fT4 concentrations than sex and age of the subjects in the 45- to 75-year age group. The estimated difference in medians, as measured by the HNR study, was lowest in the SHIP study, −0.47 (95% CI: −0.53; −0.41) for men and −0.41 (−0.53; −0.41) for women. The Rotterdam study had the highest difference in medians for both men and women (men: 0.56 with 0.44; 0.68 and women: 0.62 with 0.46; 0.78). The lowest median TSH concentrations, across all age categories considered, were seen in the German cohorts. Conclusions Comparison of thyroid function parameters and iodine in elderly subjects between six comparable cohort studies from Germany and Europe showed a significant influence of region, which exceeded the sex and age dependence of the parameters. Schlüsselwörter Thyreoidea-stimulierendes Hormon - Jod - Referenzbereich - Alter - Geschlecht Key words thyroid stimulating hormone - iodine - reference range - age - sex * geteilte Letztautorenschaft 04 October 2022 © 2022. Thieme. All rights reserved. Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart, Germany Literatur 1 Hollowell JG, Staehling NW, Flanders WD. et al. 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