Introduction: The extent of lipid peroxidation (LPO) is critical for the safe use of in all-in-one (AiO) parenteral nutrition (PN) admixtures. Admixed nutrients, such as trace elements or drugs, can further induce LPO. However, no well-defined and rapid lab assay exists for routine quantification of the most relevant toxic end products. Polyunsaturated fatty acids (PUFA), essential lipid components in PN and regular food, are highly susceptible to (per-)oxidation, forming toxic byproducts like malondialdehyde (MDA), 4-hydroxy-2-hexenal (HHE), and 4-hydroxy-2-nonenal (HNE). These compounds compromising PN quality and pose potential health risks, particularly for vulnerable PN-dependent patients.

Objectives: The aim is to develop and characterize a novel assay capable of simultaneously detect and quantify these three key byproducts with high stability, reliability, and sensitivity.

Methods: HPLC-UV quantification with a Luna C8(2) 50mm x 3 mm, 3µm particles column in a gradient mode (H2O: AcN 95% to 5%) and 3D-field UV-VIS spectra for qualitative analysis. Pure standards and Smofkab" /> Introduction: The extent of lipid peroxidation (LPO) is critical for the safe use of in all-in-one (AiO) parenteral nutrition (PN) admixtures. Admixed nutrients, such as trace elements or drugs, can further induce LPO. However, no well-defined and rapid lab assay exists for routine quantification of the most relevant toxic end products. Polyunsaturated fatty acids (PUFA), essential lipid components in PN and regular food, are highly susceptible to (per-)oxidation, forming toxic byproducts like malondialdehyde (MDA), 4-hydroxy-2-hexenal (HHE), and 4-hydroxy-2-nonenal (HNE). These compounds compromising PN quality and pose potential health risks, particularly for vulnerable PN-dependent patients.

Objectives: The aim is to develop and characterize a novel assay capable of simultaneously detect and quantify these three key byproducts with high stability, reliability, and sensitivity.

Methods: HPLC-UV quantification with a Luna C8(2) 50mm x 3 mm, 3µm particles column in a gradient mode (H2O: AcN 95% to 5%) and 3D-field UV-VIS spectra for qualitative analysis. Pure standards and Smofkab" />

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29.05.2025

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