Objectives: Eicosapentaenoic acid (EPA) and arachidic acid are long-chain fatty acids with potential therapeutic benefits. However, their role, along with short-chain fatty acids (SCFAs), polyunsaturated fatty acids (PUFAs), and oleic acid, in predicting treatment response remains unclear.
Methods: This study evaluates the association between fatty acid intake and therapy response in 62 MM patients by diet tracking and serum metabolomics analysis in 21 patients using the MxP Quant 500 XL kit. Bayesian logistic regression, Spearman, and Pearson correlations assessed factors associated with complete remission (CR), therapy outcomes CR or very good partial response (VGPR) and plasma cell infiltration.
Results: EPA intake positively predicted CR (β=29.08, p=0.037) after induction therapy. Arachidic acid was significantly linked to achieving CR or VGPR after stem cell transplantation (β=28.43, p=0.0117). Plasma cell infiltration correlated with omega-3 fatty acids (r=-0.293, p<0.001), PUFAs (r=-0.418, p<0.001), SCFAs (r=-0.324, p<0.001), and oleic acid (r=-0.365, p<0.001) from dietary sources. Metabolomics data showed similar correlations for propionic acid (r=-0.367, p<0.001) and isovaleric acid (r=-0.397, p<0.001).
[Figure 1]:" /> Introduction: Multiple myeloma (MM) is a hematologic malignancy characterized by plasma cell infiltration of the bone marrow. Nutritional factors, particularly anti-inflammatory fatty acids, may influence disease progression and therapy outcomes.
Objectives: Eicosapentaenoic acid (EPA) and arachidic acid are long-chain fatty acids with potential therapeutic benefits. However, their role, along with short-chain fatty acids (SCFAs), polyunsaturated fatty acids (PUFAs), and oleic acid, in predicting treatment response remains unclear.
Methods: This study evaluates the association between fatty acid intake and therapy response in 62 MM patients by diet tracking and serum metabolomics analysis in 21 patients using the MxP Quant 500 XL kit. Bayesian logistic regression, Spearman, and Pearson correlations assessed factors associated with complete remission (CR), therapy outcomes CR or very good partial response (VGPR) and plasma cell infiltration.
Results: EPA intake positively predicted CR (β=29.08, p=0.037) after induction therapy. Arachidic acid was significantly linked to achieving CR or VGPR after stem cell transplantation (β=28.43, p=0.0117). Plasma cell infiltration correlated with omega-3 fatty acids (r=-0.293, p<0.001), PUFAs (r=-0.418, p<0.001), SCFAs (r=-0.324, p<0.001), and oleic acid (r=-0.365, p<0.001) from dietary sources. Metabolomics data showed similar correlations for propionic acid (r=-0.367, p<0.001) and isovaleric acid (r=-0.397, p<0.001).
[Figure 1]:" />
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