Introduction: Holo-Transcobalamin (holo-TC) is the biologically active form of vitamin B12. While severe vitamin B12 deficiency has well-known clinical consequences, the relation of holo-TC within the physiological range to various health parameters in the general population is largely unknown.

Objectives: We aimed to identify cross-sectional metabolic and lifestyle correlates of serum holo-TC in a population-based sample from Northern Germany (n=874, female share 43.7%, median age 62.2 [54.3; 70.9] years).

Methods: Holo-TC was measured in serum samples applying electro-chemiluminescence. Significant metabolic and lifestyle correlates of serum holo-TC were identified in a backward selection process and included in a final linear regression model. Restricted cubic splines analyses were used to test for nonlinear associations between continuous correlates and serum holo-TC.

Results: Serum holo-TC ranged from 66.7 to 114.0 pmol/L in the overall sample, being within the normal physiological range. We identified a 10% increase in alanine aminotransferase, low-density lipoprotein cholesterol, total cholesterol, or diastolic blood pressure to confer a 1.68% [1.14; 2.22], -2.82% [-5.17; -0.39], 7.09% [2.83; 11.52], or -2.56% [-4.61; -0.45] change in serum holo-TC, respectively. Compared to no supplementation, vitamin B complex supplementation conferred 21.29% [11.85; 31.53] and females compared to males showed 11.74% [5.87; 17.94] higher serum holo-TC levels.

Conclusion: Introduction: Holo-Transcobalamin (holo-TC) is the biologically active form of vitamin B12. While severe vitamin B12 deficiency has well-known clinical consequences, the relation of holo-TC within the physiological range to various health parameters in the general population is largely unknown.

Objectives: We aimed to identify cross-sectional metabolic and lifestyle correlates of serum holo-TC in a population-based sample from Northern Germany (n=874, female share 43.7%, median age 62.2 [54.3; 70.9] years).

Methods: Holo-TC was measured in serum samples applying electro-chemiluminescence. Significant metabolic and lifestyle correlates of serum holo-TC were identified in a backward selection process and included in a final linear regression model. Restricted cubic splines analyses were used to test for nonlinear associations between continuous correlates and serum holo-TC.

Results: Serum holo-TC ranged from 66.7 to 114.0 pmol/L in the overall sample, being within the normal physiological range. We identified a 10% increase in alanine aminotransferase, low-density lipoprotein cholesterol, total cholesterol, or diastolic blood pressure to confer a 1.68% [1.14; 2.22], -2.82% [-5.17; -0.39], 7.09% [2.83; 11.52], or -2.56% [-4.61; -0.45] change in serum holo-TC, respectively. Compared to no supplementation, vitamin B complex supplementation conferred 21.29% [11.85; 31.53] and females compared to males showed 11.74% [5.87; 17.94] higher serum holo-TC levels.

Conclusion:

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30.05.2025

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