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Neurotrophin Receptor TrkC Predicts Good Clinical Outcome in Medulloblastoma and Other Primitive Neuroectodermal Brain Tumors

M. A. Grotzer, A. J. Janss, P. C. Phillips, J. Q. Trojanowski · Klinische Pädiatrie · 2000 · Heft 04 · S. 196-199

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1006337
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Jahr
2000
Publikation
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
M. A. Grotzer, A. J. Janss, P. C. Phillips, J. Q. Trojanowski
Ausgabe
Heft 04 / 2000
Jahrgang 212
Seiten
196-199
Erschienen: 2000-01-01 00:00:00
ISSN
0300-8630
DOI
10.1055/s-2000-10044

Zusammenfassung

Abstract. BACKGROUND: Neurotrophins and their cognate receptors TrkA, TrkB and TrkC regulate proliferation, differentiation and death of neuronal progenitor cells and may be implicated in the progression of medulloblastoma and other primitive neuroectodermal brain tumors (PNET). These common childhood brain tumors are composed of morphologically undifferentiated cells that have important similarities to neuroectodermal progenitor cells of the developing CNS. PATIENTS AND METHODS: To identify biologic prognostic factors in childhood PNET we determined expression levels of TrkC mRNA in tumor samples from 87 PNET p…

Schlagworte

Brain tumor medulloblastoma PNET prognosis Hirntumor Medulloblastom Prognose Klinische Pädiatrie