CareLit Fachartikel

Vasorelaxing effect of the potassium (K+)-channel opener pinacidil in isolated porcine ciliary arteries

Thomas Morf, Peili Zhu, Josef Flammer, Ivan O. Haefliger · Klinische Monatsblätter für Augenheilkunde · 2001 · Heft 05 · S. 338-340

Dokument
1006696
CareLit-ID
Jahr
2001
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Klinische Monatsblätter für Augenheilkunde
Autor:innen
Thomas Morf, Peili Zhu, Josef Flammer, Ivan O. Haefliger
Ausgabe
Heft 05 / 2001
Jahrgang 218
Seiten
338-340
Erschienen: 2001-01-01 00:00:00
ISSN
0023-2165
DOI
10.1055/s-2001-15894

Zusammenfassung

Abstract PURPOSE The aim of this study was to investigate the vasorelaxing properties of pinacidil (a potassium-channel-opener) in isolated porcine ciliary arteries. METHODS Isometric contractions of isolated porcine ciliary arteries were measured with a myograph system. The vessels were first precontracted with the thromboxane A2 analog U 46619 (0.1 μM), and then exposed, in a cumulative manner, to increasing concentrations of pinacidil (1 nM - 100 μM). Relaxations have been expressed in percent of the maximal contraction evoked by U 46619 (0.1 μM). RESULTS Pinacidil showed a pronounced concentration-dependent…

Schlagworte

Normaldruckglaukom vaskuläre Risikofaktoren okulärer Blutfluss Augeninnendruck Glaukom-Therapie normal tension glaucoma vascular risk factor ocular blood flow Klinische Monatsblätter für Augenheilkunde