CareLit Fachartikel
Latanoprost is a vasoconstrictor in isolated porcine ciliary arteries
Giovanni Brogiolo, Josef Flammer, Ivan O. Haefliger · Klinische Monatsblätter für Augenheilkunde · 2001 · Heft 05 · S. 373-375
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1006697
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Jahr
2001
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Zusammenfassung
Abstract PURPOSE The purpose of this study was to assess the vasoconstrictor effect of the prostaglandin F2α analog latanoprost in isolated porcine ciliary arteries. MATERIAL AND METHODS With a myograph system to measure isometric forces, porcine ciliary arteries were exposed, in a cumulative manner, to increasing concentrations of latanoprost (0.1 nM - 0.1 mM). Experiments were conducted in quiescent vessels as well as in vessels precontracted with potassium chloride (KCl; 40 mM) or endothelin-1 (10 nM). Contractions were expressed in percent of 100 mM KCl-induced contraction. RESULTS In a concentration depende…
Schlagworte
Intraokulardruck
okulärer Blutfluss
vaskuläre Risikofaktoren
Normaldruck-Glaukom
Xalatan
Intraocular pressure
normal tension glaucoma
ocular blood flow
vascular risk factor
Klinische Monatsblätter für Augenheilkunde
