CD137 mediated T cell costimulation terminates existing autoimmune disease in SLE-prone NZB/NZW F1 mice
JL Foell, B Hewes, M McCausland, S Strahotin, SP O'Neil, M Haber, AS Bapat, PN Chandler, X Yan, N Chioriazzi, MK Hoffmann, RS Mittler · Aktuelle Rheumatologie · 2003 · Heft 11
Bibliografische Angaben
Zusammenfassung
CD137 (4-1BB) is a T cell costimulatory receptor and member of the TNFR superfamily, which is expressed on activated T cells, NK cells and dendritic cells. Its natural ligand, 4-1BB ligand, is constitutively expressed on B cells and on activated antigen presenting cells. We have shown that mAbs against CD137 preferentially costimulate CD8+ T cells, protect them from apoptosis, induce CD8+ CTL mediated killing of established tumors, and suppress the development of CD4+ T cell dependent humoral immunity. The present study was undertaken to determine whether suppression of antibody production by anti-CD137 mAb affe…
