Expression and localization of hepatocellular uptake transporters, export pumps, and radixin in primary biliary cirrhosis
AT Nies, H Kojima, J König, W Hagmann, H Spring, M Uemura, H Fukui, D Keppler · Zeitschrift für Gastroenterologie · 2004 · Heft 02
Bibliografische Angaben
Zusammenfassung
The expression and localization of human hepatocellular uptake transporters and of export pumps may change in cholestatic liver diseases. Moreover, radixin, cross-linking actin with some membrane transporters, may be required for the canalicular localization of the export pump MRP2. Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease in humans. Using immunofluorescence microscopy and semi-quantitative RT-PCR, we analyzed the expression and localization of radixin, of the uptake transporters OATP2 (or OATP-C; SLC21A6, SLCO1B1), OATP8 (SLC21A8, SLCO1B3), and NTCP (SLC10A1), and of the export pum…
