CareLit Fachartikel
Enhancement of repopulation of the rat liver by fetal liver stem/progenitor cells: Comparison with bone marrow cells
M Oertel, A Menthena, MD Dabeva, DA Shafritz · Zeitschrift für Gastroenterologie · 2004 · Heft 02
Dokument
1007899
CareLit-ID
Jahr
2004
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Zusammenfassung
In previous studies, we showed 5–10% repopulation of the normal rat liver at 6 months after transplantation (Tx) with ED14 hepatoblasts. Our present study was directed at finding ways to augment the repopulation process with transplanted fetal hepatoblasts. DPPIV- F344 rats were used to follow the fate of DPPIV+ fetal liver cells after Tx in conjunction with partial hepatectomy (PH). To characterize the subpopulations of cells to be transplanted, simultaneous analysis for albumin, AFP and CK19 was established. Multiple preparations of unfractionated hepatoblasts showed 2.4% of the cells to be positive for both A…
Schlagworte
bone marrow cells
fetal liver stem/progenitor cells
hepatoblasts
liver repopulation
rat
Zeitschrift für Gastroenterologie
