CareLit Fachartikel

Primary human hepatocyte cultures as a tool for determination of neutralizing activity of antibodies against different hepatitis B virus isolates

S Boehm, UC Tausch, E Roehrl, WE Thasler, T Weiß, W Jilg · Zeitschrift für Gastroenterologie · 2004 · Heft 02

Dokument
1007904
CareLit-ID
Jahr
2004
Publikation
PDF
nein
Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
S Boehm, UC Tausch, E Roehrl, WE Thasler, T Weiß, W Jilg
Ausgabe
Heft 02 / 2004
Seiten
–
Erschienen: 2004-02-02 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2004-816184

Zusammenfassung

Selection of Hepatitis B Virus (HBV) variants with aminoacid exchanges within the hepatitis B surface antigen (HBsAg) has been reported in liver transplant recipients with failure of passive immunoglobulin prophylaxis. Alterations of the antigenic structure within HBsAg can reduce antibody binding, but the effect on viral neutralization is not well defined. Therefore we established an in vitro infection model using primary human hepatocytes as target cells for HBV to analyse the in vitro neutralizing activity of antibodies against HBsAg (anti-HBs). Hepatocytes were infected with high viremic serum samples, which…

Schlagworte

HBV HBsAg anti-HBs antibodies hepatitis B virus immunoglobulin prophylaxis neutralization primary human hepatocytes variants Zeitschrift für Gastroenterologie