Distinct expression pattern of Nup88 (karyoporin) in chronic hepatitis B virus infection
M Knöß, N Bektas, O Goreva, HU Kasper, K Breuhahn, P Schirmacher, HP Dienes, H Zentgraf, A zur Hausen · Zeitschrift für Gastroenterologie · 2004 · Heft 02
Bibliografische Angaben
Zusammenfassung
Aims: Nup88 (karyoporin) is a member of the nucleoporin family forming the nuclear pore complex (NPC). NPCs enable the bidirectional exchange between the nucleus and cytoplasm. Recent data – using a polyclonal antiserum- indicated that Nup88 is highly expressed in various neoplastic precursor lesions and tumors of different origin. We tested Nup88 expression with a new, non-commercial monoclonal antibody in normal and chronically viral infected liver tissues. Material and Methods: Immunohistochemistry (IHC) for the monoclonal Nup88 antibody (H.Z.) was established on paraffin embedded tissue. Biopsy specimens tes…
