Genotypic clarithromycin resistance of helicobacter pylori in relation to eradication therapy

The resistance of Helicobacter pylori to antimicrobial agents, and particularly to metronidazole and clarithromycin (CLA), is an important factor affecting the outcome of standard treatments for H. pylori eradication. Aim: To study the occurrence of CLA-R of in H. pylori-infected patients in relation to previous eradication therapy. Patients: 190 H. pylori-infected adults suffering from peptic ulcer disease, erosive gastroduodenitis or nonulcer dyspepsia. Of them, 55 had received previous eradication therapy with a CLA-based regimen. Samples from a group of 135 pts who had never been given CLA-based eradication…