A novel anti-inflammatory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis
T Letoha, T Takács, A Szabolcs, Z Rakonczay, C Somlai, I Varga, J Kaszaki, E Duda, E Kusz, B Penke · Zeitschrift für Gastroenterologie · 2004 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: A previous finding demonstrated that a cell-permeable peptide containing the nuclear localization sequence of the p50-NF-ęB1 subunit of NF-ęB inhibits the nuclear import of NF-ęB and suppresses systemic inflammatory responses in vivo. To enhance efficacy of the substance, we replaced the cell permeable motif with the more efficient cell transporter penetratin. In vitro Luciferase reporter gene assay with pNF-ęB-Luc (in LPS stimulated RAW 264.7 macrophages and TNF stimulated L929 fibroblasts) revealed that our newly designed peptide named PN50 could suppress transcription activity of NF-ęB. Aim: To as…
