The histochemical distribution of capsaicin receptors, substance P and calcitonin gene related peptide in the indomethacin treated rats without and with administration of omeprazol

Aims: It is well known that the indomethacin produced gastric mucosal damage in the fundus during 4 hours period. Earlier the possible role of vascular permeability has been studied in this model (Mózsik et al.: Exp. Clin Gastroenterol. 3: 2O5–215, 1993). Recently the possible preventive role of capsaicin was indicated against the indomethacin-induced gastric mucosal damage in rats. (Mózsik, Abdel-Salam, Szolcsányi: Capsaicin-Sensitive Afferent Nerves in the Gastric mucosal Damage and Protection, Akadémiai Kiadó, Budapest, 1997). Aim of this study was to detect the immundistribution of CR, CGRP and SP in the rat…