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Aberrantly regulated genes in TEL/AML1 positive leukaemia

U Hentschel, N Feldhahn, F Berthold, M Müschen, M Fischer · Klinische Pädiatrie · 2004 · Heft 05

Dokument
1008353
CareLit-ID
Jahr
2004
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
U Hentschel, N Feldhahn, F Berthold, M Müschen, M Fischer
Ausgabe
Heft 05 / 2004
Seiten
–
Erschienen: 2004-05-27 00:00:00
ISSN
0300-8630
DOI
10.1055/s-2004-828574

Zusammenfassung

TEL/AML1 is the most common chromosomal rearrangement in pediatric cancer, occurring in approximately 25% of acute lymphoblastic leukaemia (ALL). To reveal the molecular mechanisms underlying the pathogenesis of this disease, we have generated gene expression profiles from two patients with this rearrangement using serial analysis of gene expression. We sequenced a total of 72.000 tags. Libraries were compared to existing gene expression profiles of normal B cells covering major steps of B cell development that have previously been generated (Feldhahn et. al. 2002 PNAS). In addition, we compared the data to exis…

Schlagworte

Klinische Pädiatrie