Differential effects of TrkA or TrkB expression on DNA repair capacity might contribute to the genomic stability of SY5Y neuroblastoma cells
J Schulte, D Dobrzinski, S Kuhfittig-Kulle, E Feldmann, A Schramm, H Stephan, L Klein-Hitpass, W Havers, P Pfeiffer, A Eggert · Klinische Pädiatrie · 2004 · Heft 05
Bibliografische Angaben
Zusammenfassung
The capacity to repair DNA double strand breaks (DSB) is crucial for genomic stability. The non-homologous end-joining pathway (NHEJ) for DNA repair is an important caretaker of the mammalian genome. High expression of TrkA is associated with favorable prognosis of neuroblastoma and a lack of structural chromosomal changes, whereas TrkB is expressed on aggressive neuroblastomas with high genomic instability. We here examined the contribution of TrkA or TrkB expression to the regulation of the NHEJ-pathway in neuroblastoma using SY5Y cells transfected with TrkA or TrkB. NHEJ activity was determined in cell-free e…
