Treatment of Hyperhomocysteinemia in Orthotopic Liver Transplant Recipients with a Naturally Occurring Predominant Form of Folate (L–5-Methyltetrahydrofolic Acid) vs. Folic Acid

Hyperhomocysteinemia is frequently associated with folate deficiency. Homocysteine (HCY), an amino acid, is metabolized to methionine in a 5-methyltetrahydrofolate (5-MTHF) depending reaction. Hyperhomocysteinemia is a described risk factor of cardiovascular diseases. Liver transplant recipients have an increased cardiovascular risk because of obesity, arterial hypertension, diabetes mellitus, and hyperlipidemia. We previously described HCY as an additional risk factor for vascular complications in these patients. The aim of this study is (1) the treatment of hyperhomocysteinemia in liver transplant recipients w…