Cortical and Pyramidal Tract Pathology in ALS Patients as Detected by Voxel-Based Morphometry and Diffusion Tensor Imaging
J Grosskreutz, J Frädrich, J Kaufmann, H Ribanna, J Bufler, R Dengler, HJ Heinze, T Peschel · Klinische Neurophysiologie · 2004 · Heft 08
Bibliografische Angaben
Zusammenfassung
Objective: We have attempted to detect brain abnormalities in ALS patients by using an unbiased approach with optimized voxel-based morphometry and diffusion tensor imaging in comparison to healthy controls. Background: In ALS patients, the presence of cerebral atrophy on conventional and scientific neuroimaging has been a matter of debate. We therefore applied voxel-based morphometry (VBM) and diffusion-tensor imaging (DTI) as powerful unbiased whole-brain methods to detect subtle regional differences in grey matter volume (GMV) and fractional anisotropy (FA). Methods: 17 ALS patients diagnosed according to the…
