Voxel-Guided Morphometry (VGM) for Intraindividual Assessment of Delayed Differential Alterations in Human Brain Volume after Cerebral Infarction

In our study, we examined delayed volume alterations in brain areas remote from the lesion proper in 6 stroke patients with an incomplete MCA infarction. MRI scans were carried out 7 days and between 3 and 16 months after stroke onset. Patients were examined by a 3D FLASH MRI scan. The brains from the same patient at two different times were matched to each other using an extended principal axes theory, a cross-correlation based procedure and a fast automated multiresolution full-multigrid movement model [2]. Brains were matched with a 3-step procedure: (i) ePAT and (ii) cross-correlation procedure for linear co…