Effect of Endotoxin on the Peripheral Nerve Leading to Critical Illness Polyneuropathy

Introduction: Critical illness polyneuropathy (CIP) is a mixed motor and sensory axonal polyneuropathy which complicates sepsis or hypotension and occurs with the development of multiple organ failure. CIP is a relatively common problem in intensive care units. It has a frequency of 33% to 100% depending on the criteria used for the diagnosis and the type of patients. Patients who survive recover within weeks, in case of mild CIP, or within months, in case of severe CIP. In this study we investigated electrophysiological, microbiological and inflammatory parameters to evaluate factors possibly associated with th…