Novel Deep Brain Stimulation Techniques based on Stochastic Phase Resetting Principles

Synchronization of neuronal activity appears to be the hallmark of several neurological diseases like Parkinson's disease and essential tremor. In patients who do not respond to medication, permanent electrical high-frequency (>100Hz) deep brain stimulation (DBS) turned out to be the therapeutic gold standard. This standard DBS basically mimics the effect of tissue lesioning. However, its mechanism is still not sufficiently understood. For this reason, we have investigated stimulation-induced dynamics in mathematical models of relevant target areas. We have developed novel stimulation techniques using methods fr…