Enriched environment and physical activity increase cell proliferation and improve motor skills in 6-OHDA modell of Parkinson's disease

Voluntary physical activity and an enriched environment are robust physiological stimuli of neurogenesis in the healthy adult dentate gyrus. Recently generation of newborn tyrosine hydrolase (TH+) positive neurons has also been found in the adult rodent Substantia migra pars compacta (SNc), a yet unknown neurogenic zone of the adult CNS in a rodent model of Parkinson's disease. This phenomenon implicates the existence of a putative endogenous regenerative potential of the adult SN. The molecular and cellular mechanisms of adult neurogenesis are not defined yet, neither is known if the generation of new nigral TH…