Monocyte-derived HLA-G, a strong inhibitor of autologous CD4 T-cell activation, is upregulated by interferon-β in vitro and in vivo: rationale for the therapy of multiple sclerosi…
M Mitsdörffer, B Schreiner, BC Kieseier, O Neuhaus, J Dichgans, HP Hartung, M Weller, H Wiendl · Aktuelle Neurologie · 2004 · Heft 09
Bibliografische Angaben
Zusammenfassung
Objective: To investigate the role of monocyte-derived HLA-G in the immune-regulatory processes of MS and its implications for current immune-modulatory therapies. Background: HLA-G is a non-classical MHC molecule that has been attributed chiefly negative immune regulatory functions. Antigen presenting cells are important for the maintenance of immune tolerance and considered to play a critical role in promoting the (re)activation of potentially autoreactive T cells in multiple sclerosis (MS). Methods: HLA-G expression on peripheral monocytes was analyzed by QRT-PCR, flow cytometry and ELISA in MS patients and c…
