NTCP Down-Regulation During Obstructive Cholestasis Occurs Cytokine-Independently in Rats and Mice
A Geier, G Zollner, CG Dietrich, M Wagner, P Fickert, N van Rooijen, H Denk, S Matern, C Gartung, M Trauner · Zeitschrift für Gastroenterologie · 2005 · Heft 01
Bibliografische Angaben
Zusammenfassung
Cholestatic liver injury is a complex pathophysiologic situation not only associated with accumulation of bile acids but also with activation of proinflammatory cytokines. Common bile duct ligation (CBDL) induces sustained downregulation of the Na+/taurocholate cotransporter (Ntcp) in rat and mouse liver. While repression of Ntcp during endotoxemia is cytokine-mediated (Geier et al. Hepatology 2003), it is unclear whether inflammatory cytokines contribute to this down-regulation in obstructive cholestasis. Cytokine inactivation in CBDL rats and mice was either performed directly with TNFα (etanercept 8mg/kg i.p…
