Multivariate Gene Expression Profiling Reveals Common Expression Patterns Associated to Acute Phase Reaction, Lipid Metabolism and Proliferation in Regenerating Livers With and Wi…

Under certain conditions, when the proliferative capacity of hepatocytes is severely impaired, liver regeneration can be accomplished by hepatic progenitor cells (oval cells). So far, only few factors have been identified to be uniquely regulated during oval cell activation. Using macroarray analysis of 1,176 spotted genes in a rat model of oval cell proliferation (AAF treatment and partial hepatectomy), we identified 11 differentially expressed genes compared to appropriate control models (AAF treatment and sham operation or AAF treatment alone). Three genes could be characterized as acute phase proteins (insul…