Functional Mapping of Hepatitis C Virus (HCV)-Dendritic Cell Interaction Using HCV-like Particles
H Barth, A Ulsenheimer, GR Pape, HM Diepolder, C Neumann-Haefelin, B Gissler, R Klein, R Thimme, HE Blum, TF Baumert · Zeitschrift für Gastroenterologie · 2005 · Heft 01
Bibliografische Angaben
Zusammenfassung
Hepatitis C virus (HCV) is a major cause of chronic hepatitis worldwide. Interaction of dendritic cells (DCs) with viral particles may play an important role in the immunopathogenesis of HCV infection. We have previously demonstrated that uptake of hepatitis C virus-like particles (HCV-LPs) by monocyte-derived immature DCs leads to an efficient antigen processing and presentation on HLA class II molecules. In this study we (i) mapped the viral envelope epitopes mediating HCV-LP binding to DCs, (ii) analyzed the functional role of cellular HCV E2 binding proteins for capture of HCV-LPs to DCs and (iii) determined…
