Hepatitis C Virus Structural Proteins and Activation of Toll-Like Receptors
M Hoffmann, P Henneke, S Weichert, H Barth, B Gissler, DT Golenbock, HE Blum, TF Baumert · Zeitschrift für Gastroenterologie · 2005 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background and aim: Toll-like receptors (TLRs) are pathogen recognition molecules that activate the innate immune system. Recognition of pathogen-associated molecular patterns (PAMPs) by TLRs induces the activation of genes, important for an effective host defense. Recent studies have indicated that innate immune response induced by viruses (HSV, CMV, RSV and measles virus) is mediated by viral structural proteins and TLR–2 or –4 interaction. We have demonstrated that hepatitis C virus-like particles (HCV-LPs) derived from the HCV structural proteins activate dendritic cells (DCs). In this study we aimed to anal…
