Calcium-sensing receptor (CASR) A986s polymorphism and bone disease in primary biliary cirrhosis and Wilson disease
A Folhoffer, P Lakatos, A Horváth, T Csak, J Osztovits, É Bajnok, G Speer, Z Nagy, A Habior, I Tornai, P Lakatos, F Szalay · Zeitschrift für Gastroenterologie · 2005 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background/Aim: Genetic factors have been implicated in the pathogenesis of osteoporosis, a common disorder in primary biliary cirrhosis (PBC) and decreased bone mineral density (BMD) with elevated serum osteoprotegerin and beta-cross-laps was described by our group in Wilson disease (WD). The CaSR “A986S“ genotype was shown to affect serum Ca2+ levels, and an association between the polymorphism and BMD was reported. Our aim was to investigate the A986S CaSR polymorphism and BMD in Hungarian PBC and WD patients. Patients and methods: 53 female PBC patients (age:55.4yrs, range: 36–81yrs, AMA M2 positive, stage I…
