Analysis of gene expression profiles of cancer cells with acquired mitoxantrone resistance

Cancer patients with similarly diagnosed tumours can have markedly different treatment responses. So far, individual markers have failed to correctly predict resistance against anticancer agents. We hypothesized that gene expression patterns attributable to chemotherapy resistant cells can help to identify key regulatory genes and predict response. We contrasted the expression profiles of four different human tumor cell lines of gastric (EPG85–257), pancreatic (EPP85–181), colon (HT29) and breast (MDA-MB-231) origin and their counterparts resistant to the topoisomerase inhibitor mitoxantrone. Mitoxantron is wide…