5-amino salicylic acid protects the colon against trinitrobenzene sulphonic acid injury through hemoxigenase-1 enzyme induction

5-amino salicylic acid (5-ASA) is successfully used in the treatment of inflammatory bowel disease (IBD). The better understanding of mechanism of action of 5-ASA may lead further insight to the etiology of IBD: On the other hand, the induction of the hemoxygenase-1 (HO-1) enzyme is involved in the maintenance of intestinal mucosal integrity. Aim: We examined the role of HO-1 induction in 5-ASA-evoked protection against experimental colitis. Methods: For provocation of colonic inflammation, 2,4,6-trinitrobenzene sulphonic acid (10mg/kg) was administered intrarectally (i.c.) to male Wistar rats. The extent of les…