Infliximab treatment of a fulminate Crohn's disease patient also presenting celiac disease symptoms. Case presentation

Crohn's disease is a chronic, non-specific transmural colonic inflammatory disease of unknown etiology which can affect the whole gastrointestinal tract. According to recent literature, tumor necrosis factor alpha (TNF-alpha) plays an important role in the development of mucosal inflammation. Infliximab, a monoclonal TNF-alpha antibody which by binding to soluble and transmembrane TNF as well can block its effects in vivo and in vitro. The authors present the case of a young Crohn's patient in whom abdominal wall abscesses and fistula developed besides pancolitis. The disease developed fulminantly so there was n…