High dose dopamine agonist treatment and combination of dopamine agonists

Moving towards a more dopamine agonist based therapy is often an effective way to counteract motor fluctuations in patients with advanced Parkinson's disease. It is thereby an impression that higher doses of dopamine agonists than those normally recommended can lead to further improvements compared to treatment with dopamine agonists in the normal dose range. There are now a number of open-label clinical studies with different dopamine agonists confirming that this might be an effective strategy. There are also single studies indicating that combining different dopamine agonists might be a further treatment alte…