A PROSPECTIVE RANDOMIZED TRIAL COMPARING CONTRAST-ENHANCED TARGETED VERSUS SYSTEMATIC ULTRASOUND GUIDED BIOPSIES: IMPACT ON PROSTATE CANCER DETECTION

Purpose: We performed a prospective randomized trial comparing less than or equal to 5 contrast-enhanced colour Doppler ultrasound targeted biopsy cores to 10 grey-scale ultrasound guided systematic biopsy cores to determine the impact on the cancer detection rate. Methods and Materials: We prospectively randomized 100 PSA screening volunteers with an elevated PSA (>1.25 ng/mL and free-to-total PSA