SLIT2/ROBO1-Induced Migration of Breast Cancer Cells

The migration of cells has an essential function in embryonic development, wound healing and the immune response, and is a prerequisite for cancer invasion and metastasis. In these processes, migration is mostly controlled by external signals such as cytokines. Recently, the chemokine receptor CXCR4 and its ligand CXCL12 (SDF-1α) have been shown to play not only a significant role in migration of leukocytes, but also in the migration and targeted metastasis of cancer cells. The interaction of SLIT, a secreted protein known for its role of repulsion in axon guidance and neuronal migration, with its receptor ROBO…