Pain suppresses spontaneous brain rhythms

The neuronal activity of the resting human brain is dominated by spontaneous oscillatory activity of primary visual, somatosensory and motor areas. These spontaneous brain rhythms are related to the functional state of a system. A higher amplitude of oscillatory activity is thought to reflect an idling state whereas a lower amplitude is associated with activation and higher excitability of a system. Here, we used magnetoencephalography and selective nociceptive cutaneous laser stimulation to investigate the effects of pain on spontaneous brain rhythms. Our results show that a focally applied brief painful stimul…