Gastric emptying (GE), major contributor for postprandial hyperglycemia in type 1 diabetes mellitus (T1DM)

Postprandial (PP) hyperglycemia has been identified as an important risk factor for cardiovascular disease. The pancreatic hormone amylin is postprandially released and inhibits gastric emptying. T1DM are amylin deficient. Accordingly, we hypothesised that 1) in contrast to current view T1DM without neuropathy should have increased GE, 2) that the latter may be an important regulator of PP glycemia, 3) Amylin substitution should normalize GE in T1DM and reduce PP glucose excursion. Methods: We studied 12 healthy subjects (HS) and 12 otherwise healthy subjects with T1DM each on two occasions after ingestion of a…