Expression of tyrosine kinases in human malignancies as potential targets for kinase-specific inhibitors

Tyrosine kinase (TK) inhibition has been identified as a promising strategy in the treatment of human malignancies and several synthetic inhibitors have been developed. While the selective blockage of specific TKs is highly effective in vitro, clinical results have been less impressive. It has been suggested that the simultaneous inhibition of multiple TKs might lead to more favourable therapeutic results in vivo. We have therefore performed a systematic analysis of intra-tumoral TK expression in order to identify potential targets for a simultaneous kinase inhibition. To this end, we have analyzed the protein e…