A Low-molecular-weight protein of H. pylori inhibits human T cell proliferation

We have previously shown that H. pylori culture supernatants and whole bacteria inhibit proliferation and induce cell cycle arrest of human T cells. This effect was independent of the known virulence factors cagA, vacA or babA and not due to changes in T cell activation or T cell response (Gastroenterology. 2005 May; 128(5):1327–39). Now we have further characterized the nature of the factor responsible for the inhibition of cell proliferation and signal transduction pathways involved in the effect. Water extracts of H. pylori culture supernatants were analyzed by gel-filtration and cation-exchange-chromatograph…