Pharmacological blockade and genetical ablation of the Cannabinoid-1 (CB-1) receptor stimulates peristaltic reflex and gastrointestinal transit

Background: CB-1 receptor agonists reduce cholinergic neurotransmission and intestinal propulsion. The reduction of intestinal propulsion might partially be due to CB-1 effects on neuronal circuits like the peristaltic reflex. Aim: Aim of the study was to investigate the influence of the CB-1 receptor on gastrointestinal motility by using the antagonist AM251 and the agonist Anadamide (AEA) in models of the peristaltic reflex, the gastrointestinal transit and small intestinal electrophysiology. Methods: Segments of isolated rat ileum were studied in a chambered organ bath. The reflex was initiated by electrical…