CareLit Fachartikel
L. pneumophila activated different IFN-regulated factors and induced IFNb expression
B Opitz, M Vinzing, V van Laak, B Schmeck, H Slevogt, A Flieger, N Suttorp, S Hippenstiel · Pneumologie · 2006 · Heft 02
Dokument
1010146
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Jahr
2006
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Zusammenfassung
Legionella pneumophila, a Gram-negative facultative intracellular bacteria, causes severe pneumonia (Legionnaires' diseases). Type I IFNs were so far associated with anti-viral immunity, but recent studies also clearly indicated a role of these cytokines in immune responses against (intracellular) bacteria, including L. pneumophila. Here we show that L. pneumophila induced IFNb expression in alveolar epithelial (A549) cells. Accordingly, we found that different lung epithelial cells including A549 expressed IFN-regulated factor (IRF)-3, and interestingly also IRF5 and IRF7. Whereas IRF5 was constitutively locate…
Schlagworte
Pneumologie
