Parametric analysis of cerebral ischemia with contrast enhanced ultrasound and comparision with histology in an experimental stroke model

Background: Modern ultrasound imaging modes allow to image brain perfusion with the help of echocontrast agents. The mode of continuous infusion uses the high-pulse destruction of echo contrast agents and monitors the replenishment into cerebral capillaries. We compared the value of a planimetric and a parametric analysing mode with an automated pixel analysis programme (MCE 2.9.3, Jabko Inc.) to detect perfusion defects in an experimental stroke model. Methods: In 6 rats cerebral perfusion defects were measured after craniectomy with the pulse inversion imaging mode 24 hours after induction of cerebral ischemia…