Neurophysiologic classification of Wilson's disease by using cluster analysis

Introduction: Wilson's disease (WD) is characterized by a variety of symptoms based on the hepatolenticular degeneration. The disease is currently classified according to clinical symptoms alone into neurologic (pseudosclerotic, pseudoparkinsonic, merged type) and non-neurologic forms (asymptomatic, hepatic). Yet, electrophysiological investigations reveal subclinical lesions in several pathways of the central nervous system which are not involved into this classification scheme. Question: Do electrophysiological lesions reflect the classification scheme based on hepatolenticular symptoms? Tab. 1: Distribution o…